About PBC | Mirum

What is PBC?¹

Primary biliary cholangitis (PBC) is a progressive inflammatory liver disease that causes the small bile ducts in the liver to become injured and inflamed—and eventually destroyed. When there are no bile ducts, bile builds up and causes liver damage, ultimately requiring a liver transplant for many patients.

While PBC affects mostly women, men may also develop this condition. The exact cause is unknown, but it may be linked with issues in the immune system. People with a family member who has PBC may also have a higher chance of developing it.

Learn about our study in itch in PBC

We are inviting patients aged 18 and over diagnosed with PBC to participate in a study of an investigational medicine for potentially treating itch associated with PBC.

VANTAGE Study

How is PBC diagnosed?²

Doctors may diagnose PBC based on your medical and family history, a physical exam, and the results of medical tests. Medical tests used to diagnose PBC may include blood tests, imaging tests, and liver biopsy.

Treatments that may be recommended to try to control itch related to PBC. 

These may not be effective for everyone.³

Antihistamines
Cholestyramine
Rifampin
Opioid antagonists
Sertraline

Enroll in our clinical study

In a clinical study, an investigational medicine, like volixibat, is tested on volunteers to verify its safety and efficacy compared to a placebo with no active ingredients.⁴

Learn about the VANTAGE Study

References

1. Mayo Clinic. Primary biliary cholangitis. Accessed February 10, 2025. https://www.mayoclinic.org/diseases-conditions/primary-biliary-cholangitis/symptoms-causes/syc-20376874. 2. National Institute of Diabetes and Digestive and Kidney Diseases. Primary biliary cholangitis. National Institutes of Health. Accessed February 12, 2025. https://www.niddk.nih.gov/health-information/liver-disease/primary-biliary-cholangitis. 3. Mayo Clinic. Primary biliary cholangitis. Accessed February 13, 2025. https://www.mayoclinic.org/diseases-conditions/primary-biliary-cholangitis/diagnosis-treatment/drc-20376880. 4. World Health Organization. Clinical trials. WHO. Accessed February 12, 2025. https://www.who.int/health-topics/clinical-trials#tab=tab_1.

What is PBC?¹

How is PBC diagnosed?²

Common symptoms of PBC¹

Enroll in our clinical study

In a clinical study, an investigational medicine, like volixibat, is tested on volunteers to verify its safety and efficacy compared to a placebo with no active ingredients.⁴

Additional resources to help you learn more about PBC

What is PBC?1

How is PBC diagnosed?2

Common symptoms of PBC1

Enroll in our clinical study

In a clinical study, an investigational medicine, like volixibat, is tested on volunteers to verify its safety and efficacy compared to a placebo with no active ingredients.4

Additional resources to help you learn more about PBC

Our “at-home” option

What is PBC?¹

How is PBC diagnosed?²

Common symptoms of PBC¹

In a clinical study, an investigational medicine, like volixibat, is tested on volunteers to verify its safety and efficacy compared to a placebo with no active ingredients.⁴