What is PSC?¹

Primary sclerosing cholangitis (PSC) is a rare liver disease characterized by inflammation and scarring of the bile ducts, which lead to hardening and narrowing (strictures) in the bile ducts inside or outside the liver, preventing the bile from flowing properly. PSC may also affect the lining of the large bowel wall. Many people with PSC also have inflammatory bowel disease (IBD), like ulcerative colitis (UC) or Crohn’s disease.

PSC affects people of all ages

PSC is typically diagnosed in individuals aged 30 to 40, but it can be detected at any stage of life. This condition can also impact children, with adolescents more commonly affected.¹

Learn about our study in itch in PSC

We are inviting patients aged 12 and over diagnosed with PSC to participate in a study of an investigational medicine for potentially treating itch associated with PSC.

VISTAS Study

How is PSC diagnosed?

Doctors may diagnose PSC based on your medical and family history, a physical exam, and the results of medical tests. Medical tests used to diagnose PSC may include blood tests, imaging tests, and liver biopsy.²

In some cases, PSC is diagnosed after routine blood tests for IBD suggest bile duct injury. Other common symptoms, such as itch or jaundice, might help identify PSC.¹

Common symptoms of PSC¹

Itch

Fatigue

Pain

Yellowing of the skin and eyes (jaundice)

Depression

Treatments that may be recommended to try to control itch related to PSC.

These may not be effective for everyone.³

Antibiotics
Antihistamines
Bile acid sequestrants
Opioid antagonists
Ursodeoxycholic acid
(UDCA)

Enroll in our clinical study

In a clinical study, an investigational medicine, like volixibat, is tested on volunteers to verify its safety and efficacy compared to a placebo with no active ingredients.⁴

Learn about the VISTAS Study

Additional resources to help you learn more about PSC

PSC Patient Brochure

Learn from Patient Advocacy

References

1. Mayo Clinic. Primary sclerosing cholangitis. Updated October 5, 2022. Accessed February 12, 2025. https://www.mayoclinic.org/diseases-conditions/primary-sclerosing-cholangitis/symptoms-causes/syc-20355797. 2. National Institute of Diabetes and Digestive and Kidney Diseases. Primary sclerosing cholangitis. National Institutes of Health. Accessed February 12, 2025. https://www.niddk.nih.gov/health-information/liver-disease/primary-sclerosing-cholangitis. 3. Mayo Clinic. Primary sclerosing cholangitis. Updated October 5, 2022. Accessed February 12, 2025. https://www.mayoclinic.org/diseases-conditions/primary-sclerosing-cholangitis/diagnosis-treatment/drc-20355802. 4. World Health Organization. Clinical trials. WHO. Accessed February 12, 2025. https://www.who.int/health-topics/clinical-trials#tab=tab_1.

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What is PSC?1